Fig. 4

Tyrobp deletion ameliorates aspects of the Q175 motor phenotype. Motor behavior in Q175 mice was assessed at 6 and 9 months of age. A Accelerating rotarod test was performed for three consecutive days (three trials per day). The latency to fall data at 6 months is represented per test and group as mean ± SEM. The latency to fall at 9 months is averaged per day (WT n = 8; Tyrobp^(−/−) n = 8; Q175 n = 13; Q175;Tyrobp^(−/−) = 12). B Balance beam assay is shown as time to cross 30 frames and number of frames crossed in 2 min (WT n = 7; Tyrobp^(−/−) n = 8; Q175 n = 14; Q175;Tyrobp^(−/−) = 13). C Vertical pole assay is shown as time to turn (left) and time to descend (right), which were recorded after placing the mice upwards to the pole. Three trials were conducted (WT n = 8; Tyrobp^(−/−); n = 8; Q175 n = 14; Q175;Tyrobp^(−/−) = 13). Data represent the mean ± SEM. Each point represents data from an individual mouse. Statistical analysis was performed using Two-way ANOVA followed by Bonferroni’s post hoc test, *p < 0.05; **p < 0.01; ***p < 0.001, ****p < 0.0001