Fig. 7

Schematic diagram illustrating the impact of astrocytic CEBPD/MMP8 axis on oxidative stress in ouabain-induced manic-like mice. Ouabain can induce glial cell activation and enhance the expression of astrocytic CEBPD, particularly in the CA1 region. Subsequently, astrocytic CEBPD can regulate the expression of MMP8, which, in turn, promotes oxidative stress by increasing nitrotyrosine levels. Treatment with M8I (an inhibitor of MMP8) reduces glial cell activation and oxidative stress in ouabain-injected mice, decreasing manic-like behavior. Ultimately, this sequence of events reveals that neuroinflammation is linked to manic-like behavior as occurs in bipolar disorder through the activation of the astrocytic CEBPD/MMP8 pathway