Table 1 A summary of the cell type in retina and choroid that express pattern recognition receptors

TLR1

RPE - human primary culture [61, 82], Choroidal endothelial cells – human ex-vivo [65], Choroidal melanocytes – human primary culture [107] Microglia - mouse ex-vivo [75,76,77,78,79,80]

TLR2

RPE - human primary culture [61, 82], human and mice ex-vivo [84], Choroidal endothelial cells – human ex-vivo [65], Retinal endothelial cells – human ex-vivo [65], Choroidal melanocytes – human primary culture [107, 108], Müller glia – mouse primary culture [110] and mouse ex-vivo [63, 110], Astrocyte – human ex-vivo [77] and mouse primary culture [111], Microglia – human ex-vivo [77] and mouse ex-vivo [75,76,77,78,79,80]

TLR3

RPE - human primary culture [61, 82], Retinal endothelial cells – human primary culture [64], Choroidal endothelial cells – human ex-vivo [65], mouse and human primary culture [190], Retinal endothelial cells – human ex-vivo [65], Choroidal melanocytes – human primary culture [107], Müller glia – mouse primary culture [110]and mouse ex-vivo [63, 110] Astrocyte – human ex-vivo [77], Microglia- human ex-vivo [77] and mouse ex-vivo [75,76,77,78,79,80], Cone photoreceptor – 661 cell line [116, 117]

TLR4

RPE - human primary culture [61, 82, 90], Choroidal endothelial cells – human ex-vivo [65], Retinal endothelial cells – human ex-vivo [65, 106], mouse ex-vivo [105, 106], Choroidal melanocytes – human primary culture [107], Müller glia – mouse primary culture [110], mouse ex-vivo [63, 110, 118] and macaque ex-vivo [115] Astrocyte – human ex-vivo [77], Microglia - human ex-vivo [77] and mouse ex-vivo [75,76,77,78,79,80], Retinal ganglion cell – mouse ex-vivo [114] and macaque ex-vivo [115], Amacrine cell – Macaque ex-vivo [115], Bipolar cell – Macaque ex-vivo [115], Photoreceptor cell – mouse ex-vivo [118]

TLR5

RPE - human primary culture [61, 82], Choroidal endothelial cells – human ex-vivo [65], Retinal endothelial cells – human ex-vivo [65], Choroidal melanocytes – human primary culture [107], Müller glia – mouse primary culture [110] and mouse ex-vivo [63, 110]), Retinal ganglion cell – Macaque ex-vivo [115]

TLR6

RPE - human primary culture [61, 82], Choroidal endothelial cells – human ex-vivo [65], Retinal endothelial cells – human ex-vivo [65], Choroidal melanocytes – human primary culture [107, 108], Microglia - mouse ex-vivo [75,76,77,78,79,80], Retinal ganglion cell – Macaque ex-vivo [115], Amacrine cell – Macaque ex-vivo [115], Bipolar cell – Macaque ex-vivo [115]

TLR7/8

Microglia - mouse ex-vivo [75,76,77,78,79,80], RPE – mice ex-vivo [83], Müler glia – mouse ex-vivo [115], Macaque ex-vivo [115], Retinal ganglion cell – Macaque ex-vivo [115], Amacrine cell – Macaque ex-vivo [115], Bipolar cell – Macaque ex-vivo [115]

TLR9

RPE - human primary culture [61], Choroidal endothelial cells – human ex-vivo [65], Retinal endothelial cells – human ex-vivo [65], Müller glia – mouse ex-vivo [76]

TLR10

Retinal endothelial cells – human ex-vivo [65]

NLRP3

RPE – ARPE-19 cells [62, 94, 95, 98, 101, 102, 121], mouse primary culture [190], mouse ex-vivo [113] and human ex-vivo [97, 121], Müller glia – mouse ex-vivo [113], Microglia – mouse ex-vivo [113, 119], Astrocytes – mouse ex-vivo [113], Retinal ganglion cell – mouse ex-vivo [113], Cone photoreceptor cells – mouse ex-vivo [119]