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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: P2X7 receptor antagonists modulate experimental autoimmune neuritis via regulation of NLRP3 inflammasome activation and Th17 and Th1 cell differentiation

Fig. 6

BBG reduced Th17 cell infiltration and the expression of inflammatory cytokines in the sciatic nerve of EAN rats. Sciatic nerves were harvested for immunofluorescence staining and qRT-PCR at the peak of EAN. (A) Fluorescence photomicrographs showing Th17 cells (arrows) in the sciatic nerves of EAN rats. Scale bars, 50 μm. (B) Th17 cells were quantified using by ImageJ software. Numbers of Th17 cells per square millimeter in the sciatic nerves. (C-F) mRNA levels of inflammatory cytokines IL-17, TNF-α, IFN-γ, and IL-2 in the sciatic nerve. Experiments were performed in triplicate (n = 6 per replicate) with similar results. BBG-P, preventative BBG group; BBG-T, therapeutic BBG group. *p < 0.05, **p < 0.01

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Journal of Neuroinflammation

ISSN: 1742-2094