Fig. 3

Metabolic patterns of brain tissue affected by tau pathology. Univariate and multivariate analyses of metabolic patterns found in the medulla oblongata of 10-month-old SHR-24 Tg rats compared with age-matched controls (SHR). A Principal component analysis (PCA) and orthogonal partial least square discriminant analysis (OPLS-DA) B Metabolic map showing results from significance testing for lipids – student’s t-test and fold change. The size of each bubble represents the statistical significance (p-value), and color and shade indicate the level of fold change between SHR-24 Tg and control groups. C Age-related changes of the most distinctive lipid classes (data are presented as median intensities with 95% confidence intervals). E Enrichment pathway analysis of metabolomics data. The biochemical pathways were assessed using statistical significance (p-value) and enrichment ratio. F Metabolic map showing results from significance testing for metabolites– student’s t-test and fold change. G Age-related changes of short-chain, long-chain, and hydroxylated acylcarnitines, myoinositol, and citrulline (data are presented as median intensities with 95% confidence intervals). Abbreviations LPE – lysophosphatidylethanolamines, PE – phosphatidylethanolamines, PS – phosphatidylethanolserines, PC – phosphatidylcholines, LPC – lysophosphatidylcholines, SM – sphingomyelins, CER – ceramides, HCER – hexosyl-ceramides, H2CER – dihexosyl-ceramides, DAG – diacylglycerols, TAG – triacylglycerols, PI – phosphatidylinositols, PG – phosphatidylglycerols, CE – cholesteryl esters, FA – fatty acids, PCO – plasmenyl phosphatidylcholines, LPCO – plasmenyl lysophosphatidylcholines, PEO – plasmenyl phosphatidylethanolamines, LPEO – plasmenyl lysophosphatidylethanolamines