Fig. 8
From: Changes in lipid metabolism track with the progression of neurofibrillary pathology in tauopathies
Tau pathology switches the energy metabolism to fatty acid oxidation. A-B Immunofluorescence staining of neuron-specific glucose transporter 3 (GLUT3) in the medulla oblongata from control and transgenic animals. Representative images of GLUT3 (green), NeuN (red), and DAPI staining (blue). C Representative images of 8-month-old control and transgenic animals. Scale bar 20 μm. D. Quantification of GLUT3 mean fluorescence intensity in brain tissue. Quantification of relative fluorescent intensity showed a decrease of GLUT3 in transgenic animals (8-months old animals: CN: 25.07 ± 1.43, Tg: 20.91 ± 0.54; p = 0.035; 10-month-old animals: CN: 28.37 ± 1.03, Tg: 22.36 ± 1.67; p = 0.022; n = 5; mean ± SD, student’s t-test with p-value). E Changes of long-chain, hydroxylated, short-chain ACs and free carnitine in brain tissue of control and transgenic rats (data are presented as median intensities with 95% confidence intervals)