Fig. 13
From: CSF1R antagonism results in increased supraspinal infiltration in EAE
Effect of CSF1R antagonism on the expression of CSF1R and its ligands during EAE. A Csf1r transcript levels are lower in the PD compared to CD CNS during EAE. There were no differences in the transcripts of Csf1 and Il34. B CSF1R (CD115) expression was detected using flow cytometry in Ly6C+ and Ly6C- microglia, monocytes, macrophages, and neutrophils in pooled brain and spinal cord (CNS), and SLOs during EAE. C Quantification of B. Data are shown as means ± SD, A: n = 9–12; B: n = 16 *p < 0.05, **p < 0.005, ***p < 0.0005, ****p < 0.00005