Fig. 3
From: CSF1R antagonism results in increased supraspinal infiltration in EAE
CSF1R antagonism ameliorates EAE clinical severity. A Schema of experimental design. B Classical EAE neurological symptoms onset was delayed, and severity was milder in PD compared to CD mice. C Peak and cumulative EAE scores were lower in PD compared to CD mice. D Microglia (CD45loCD11b+) are depleted in pooled brain and spinal cord tissues of PD mice in preclinical and acute EAE. E Analysis of Ly6C expression in CD45loCD11b+ cells shows that CD45loCD11b + Ly6C- cells were preferentially depleted in the CNS of PD mice. Representative flow plots are shown. Both male and female mice were employed. Results are shown as means ± SD; n = 44–47 CD, 40–49 PD; *p < 0.05, ****p < 0.0005