Fig. 3
The MG3 subcluster specifically increased genes for myelin-supporting functions in the Nhe1 cKO white matter tissues after stroke. a Trajectory analysis showing differential microglial states annotated by Spp1 and P2ry12. b Violin plots of myelin-supporting genes identified MG3 as the microglial subgroup with myelin-supporting features. c Nhe1 cKO exhibited increased myelin-supporting gene expressions in MG3 subtype in white matter tissues of IL hemisphere compared to WT. d Gene Ontology (GO) analysis for the top 20 biological processes of differentially expressed genes (DEGs) from MG3 subpopulation. e Ingenuine Pathway Analysis (IPA) of DEGs of MG3 subpopulation, in descending order by z score