Fig. 6

Nhe1 cKO specifically expanded an oligodendrocyte subcluster with increased phagocytosis and lactate shuttling functions in post-stroke white matter tissues. a UMAP of oligodendrocyte subtypes from CL and IL hemispheres of WT and cKO white matter tissues. b Violin plots of signature genes for homeostatic oligodendrocytes and disease-associated oligodendrocytes (DAO) in each oligodendrocyte subtype. c Trajectory analysis of oligodendrocytes annotated by cell state, oligodendrocyte subtype, or developmental pseudotime. d Split view of UMAP of oligodendrocytes in CL or IL hemispheres of WT and cKO white matter tissues. e Proportion of oligodendrocyte subtypes in CL or IL hemispheres of WT and cKO white matter tissues