Inflammation-induced TRPV4 channels exacerbate blood–brain barrier dysfunction in multiple sclerosis

Table 1 Clinical and demographic data of MS and NNC subjects

Case ID	Age at death	Sex	PMD (h)	Cause of death	Type of MS	Tissue preservation	Lesion type
MS14	65	M	7:15	Terminal liver cirrhosis	unk	FF, FFPE	1 CIA
MS32	54	M	unk	Progressive dyspnea	unk	FF	1 A/I
MS46	51	F	9:10	Euthanasia	SPMS	FF, FFPE	1 A/I 1 CIA
MS47	70	M	9:25	Euthanasia	SPMS	FF, FFPE	2 CIA
MS68	48	F	9:20	Pneumonia	unk	FF	1 A/I
MS71	67	M	7:55	Euthanasia	unk	FFPE	1 A/I
MS80	61	F	6:25	Pneumonia	SPMS	FFPE	1 A/I
MS85	67	F	11:25	Pneumonia	unk	FF, FFPE	2 A/I
MS113	61	F	10:55	Sepsis	PPMS?	FFPE	1 A/I
MS115	56	M	6:15	Assumed pneumonia	PPMS	FF, FFPE	2 A/I
MS116	66	F	9:30	Euthanasia	SPMS	FF, FFPE	1 A/I, 1 CIA
NNC19	68	M	8:40	Euthanasia	n/a	FF, FFPE	n/a
NNC95	71	F	7:50	Lung carcinoma	n/a	FFPE	n/a
NNC782	69	F	13:00	Pulmonary embolism	n/a	FFPE	n/a
NNC797	59	M	8:00	Euthanasia	n/a	FFPE	n/a
NNC880	77	M	11:25	Pneumonia	n/a	FFPE	n/a
NNC989	71	F	7:50	Lung carcinoma	n/a	FF	n/a
NNC999	74	M	10:20	Euthanasia	n/a	FF	n/a

PMD Post−mortem delay, unk unknown, n/a not applicable, PPMS primary progressive MS, SPMS secondary progressive MS, FF freshly frozen, FFPE formalin−fixed paraffin−embedded, CIA chronic inactive, A/I mixed active/inactive

ISSN: 1742-2094