Fig. 4

Cell–cell communications in JEV-infected mouse brain. A, B Circle plot showing the number of interaction (A) and interaction strength (B) of different cells in brain. The line thickness represents the number and the strength of signaling. The red lines represent JEV-infected mouse brain and blue lines represent the mock-infected mouse brain. Histogram shows interactions number and strength interaction. C, D River plot showing outgoing communication pattern of secreting cells and incoming communication pattern of target cells in mock-infected group (C) and JEV-infected group (D). E Information flow of each signaling pathway from cell–cell interaction analysis. The receptor-ligand pathways with blue text are significantly enriched in JEV-infected brain cells, and pathways with red text are significantly enriched in mock-infected mouse brain cells. F, G Number of neuronal cells communicating with other cells as ligands in mock-infected group (F) and JEV-infected group (G). H, K Bubble plots show the variable ligand-receptor pairs between neuronal cells and other cells, when the neurons are ligands (H) or receptors (F). I, J Number of neuronal cells communicating with other cells as receptors in mock-infected group (I) and JEV-infected group (J)