Skip to main content
Fig. 3 | Journal of Neuroinflammation

Fig. 3

From: Pathological high intraocular pressure induces glial cell reactive proliferation contributing to neuroinflammation of the blood-retinal barrier via the NOX2/ET-1 axis-controlled ERK1/2 pathway

Fig. 3

gp91ds-tat treatment effectively modulates the expression of major immune-related genes in H-IOP injured retina. (A) Principal component analysis shows the clustering of proteins in different samples. (B) Volcano plot showing differentially expressed proteins between H-IOP and control group, H-IOP + gp91ds-tat and H-IOP, H-IOP + gp91ds-tat and control group. (C) The Venn diagram was created by the differentially expressed data of proteins. (D) The most enriched KEGG Level 2 pathways for the 635 co-differentially expressed proteins. Hierarchical clustering illustrates distinct expression differences of immune genes between the three groups and homogeneity between groups. (E) The 10 most enriched KEGG pathways for the differentially expressed proteins. The size of the symbol represents the number of genes, and the colors represent the p-value. (F) The 10 most enriched gene ontology terms for the parental genes of the differentially expressed immune genes. Enriched GO terms are on the vertical axis, and the number of annotated differentially expressed genes associated with each GO term is indicated on the horizontal axis

Back to article page

Journal of Neuroinflammation

ISSN: 1742-2094