Fig. 1
From: Soluble CD27 is an intrathecal biomarker of T-cell-mediated lesion activity in multiple sclerosis
CSF sCD27 correlates with inflammatory lymphocytes in MS patients. (A) Levels of sCD27 in the CSF of patients with MS discovery cohort (DC) compared to other neurological disease (OND) as measured by ELISA. Plots display individual levels (dots) and mean (horizontal line) of 65 MS and 35 OND patients, statistically compared by Mann-Whitney test. (B) HCA and (C) PCA of CSF analytes and features of MS DC. (D) Plots compare the CSF levels of sCD27, CXCL13, CXCL10, CCL19, TNF and IL-10 in MS VC1 and patients OND as measured by ELISA. Plots display results from 41 MS validation cohort (VC)1 and 12 OND, statistically compared by Mann-Whitney test. (E) HCA and (F) PCA of CSF analytes and features of MS VC1. (G) Plots compare CSF levels of sCD27, BAFF and CXCL13 in MS VC2 and OND measured by ELISA. Plots display results from 30 patients with MS and 12 OND. Statistical analyses were performed by using Mann-Whitney test. (H) HCA and (I) PCA of CSF analytes and features of MS VC2