Fig. 5

P2RY12-deficient females display locomotor hyperactivity. A A sketch of the open field arena. B Schematic of the open field experimental design, conducted twice daily for two consecutive days. C P2RY12-deficient females exhibit increased cumulative distance and lack inter-session habituation. D No difference in cumulative distance traveled by P2RY12-deficient males compared to their P2RY12-sufficient littermates. E P2RY12-deficient females show increases basal locomotor on day 2 and impaired intra-session habituation. F Basal locomotor activity in P2RY12-deficient males is compared to P2RY12-sufficient counterparts. G Genotype significantly affects basal locomotion, with P2RY12-deficient showing increases activity. Statistical analysis was performed using 2-way ANOVA, with and without repeated measures for panels C–G, respectively, followed by Sidak’s post hoc test. Data are presented as mean ± SEM; significance set at p < 0.05. N = 19–23 mice per group. *p denotes p < 0.05, **p < 0.01, ****p < 0.0001