Fig. 2

Identification of neuroimmune-related lncRNAs (NILncs) and weighted gene co-expression network analysis (WGCNA). (a) Heatmap depicting the linear correlation between neuroimmune-related genes and all lncRNAs, identifying 213 NILncs based on an absolute correlation coefficient of > 0.8 with at least one neuroimmune-related gene. (b) UpSet plot showing the overlap of differentially expressed NILncs among the five subfields. Linked dots indicate overlapping among 10 rows, which represent up-regulated or down-regulated lncRNAs in each subfield. (c) Degree of enrichment of cell-type-specific markers, DELncs, and NILncs across WGCNA modules, with colors representing corrected P-values from Fisher’s exact test. (d) Top WGCNA connections of WGCNA module M92. Node size represents the number of gene co-expression connections. Red: DELncs in any subfield; blue: NILncs; yellow: differentially expressed NILncs in any subfield