Fig. 3

Identification and validation of key lncRNAs in AD pathology. (a) Venn diagram of lncRNAs within M92, DELncs, and NILncs, with 16 lncRNAs common to all three categories. (b) The extent of upregulation for the 16 common lncRNAs across all five subfields; the color represents the fold-change in pathological AD relative to controls, and the size of the circle represents the adjusted P-value (P.adjust). (c) ROC curves of the seven-lncRNA diagnostic model and seven single-lncRNA diagnostic models in distinguishing AD groups from healthy controls and AD from asymptomatic AD (AsymAD) groups of the GSE118553 dataset. AUC values for the seven-lncRNA diagnostic model in both test sets are shown. (d) GO and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis of co-expressed genes of these seven lncRNAs. BP, biological process; CC, cellular component; MF, molecular function