Fig. 4

Position and identification memory scores were higher in IL-6 KO MRL/lpr mice. Neuropsychiatric disease was assessed in IL-6 WT and IL-6 KO mice to determine the contribution of IL-6 to the behavioral features of the disease. A Performance on the object placement task is reported as a comparison of percent novelty preferences (top) or failure rates (bottom) in both genotypes. B Similarly, results of IL-6 WT vs IL-6 KO comparison on the object recognition task are presented in both continuous (top) and failure rate (bottom) forms. C Baseline activity on behavioral spectrometry was compared between genotypes to assess for the presence of any fundamental differences in locomotion or other confounding features. IL-6 WT comparisons to IL-6 KO also included testing for affective features using the following tasks: Porsolt swim (D; immobility to reflect behavioral despair), elevated plus maze (E; exploration of open area to determine anxiety-like behavior), and social preference task (data not shown). **p < 0.005; ****p < 0.0001