Fig. 8

Controlled cortical impact does not cause appreciable changes in retinal thickness, but does result in increased complement staining in the retina contralateral to injury. There is an increase in C3 staining intensity in the contralateral eye, both in A the inner retina and B the full thickness retina, that is reduced by complement inhibition. There are no significant differences detected in the ipsilateral retina. C There are no significant changes in the thickness of the retinal nerve fiber layer of either eye at 42 days after injury, as measured by optical coherence tomography in living animals. A–C one-way ANOVA with Tukey correction for multiple comparisons. *p < 0.05, **p < 0.01, ***p < 0.001. Error bars = mean ± s.e.m