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Fig. 6 | Journal of Neuroinflammation

Fig. 6

From: Itaconate alleviates anesthesia/surgery-induced cognitive impairment by activating a Nrf2-dependent anti-neuroinflammation and neurogenesis via gut-brain axis

Fig. 6

Nrf2 expression is increased in hippocampal neurons after OI treatment. a Representative immunofluorescence staining of DCX (green) and Nrf2 (red) in the hippocampal DG region. b Quantification of Nrf2 intensity in immature neurons in the DG region. c Immunofluorescence staining of Nrf2 (red) and MAP2 (green) in primary neurons. d Quantification of integrated density of Nrf2 in the primary neurons. Data are expressed as mean ± SD (n = 4), *P < 0.05, **P < 0.01, and ***P < 0.001 by one-way ANOVA

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